China (Mainland)
Assessedsupplier 
Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)- CAS NO.362-07-2
- Min.Order: 10 Kilogram
- Payment Terms: L/C,T/T,Other
- Product Details
Keywords
- Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)-? price
- Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)-? CA 362-07-2
- Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)-? supplier in China
Quick Details
- ProName: Estra-1,3,5(10)-triene-3,17-diol,2-met...
- CasNo: 362-07-2
- Molecular Formula: C19H26O3?
- Appearance: off-white soild
- Application: Used for Pesticide intermediates A n...
- DeliveryTime: 15 days after order confirmed
- PackAge: 1kg/bag, 1kg/drum or 25kg/drum or as p...
- Port: Shanghai, Ningbo, Tianjin, etc
- ProductionCapacity: 1 Metric Ton/Month
- Purity: 99%
- Storage: Stored in cool, dry and ventilation pl...
- Transportation: as per your request
- LimitNum: 10 Kilogram
Superiority
superior quality
Details
| 2-METHOXYESTRADIOL Chemical Properties |
| mp | 188-190°C |
| storage temp. | −20°C |
| solubility | DMSO: 10 mg/mL |
| form | crystalline |
| color | light yellow |
| CAS DataBase Reference | 362-07-2(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T,Xi |
| Risk Statements | 23/24/25-36/37/38-48-61-60-46-45 |
| Safety Statements | 22-26-36/37/39-45-53-36 |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | KG7537500 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| 2-METHOXYESTRADIOL Usage And Synthesis |
| Chemical Properties | Off-White Solid |
| Usage | A natural metabolite of 17?Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a |
| Usage | A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly |
| Usage | 2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity. |
| Usage | 2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2. |
| Usage | 2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function. |
| Biological Activity | Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly. |